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Version: 16.11d (Release date: 2016-11-28)
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LMB-2 Immunotoxin (Code C2513)

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Terms & Properties

Preferred Name: LMB-2 Immunotoxin

Definition: A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted). LMB-2 immunotoxin targets the interleukin 2 receptor (also known as IL-2R or CD25) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies. The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)

NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.

Display Name: LMB-2 Immunotoxin

Label: LMB-2 Immunotoxin

NCI Thesaurus Code: C2513 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0655013  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Anti-Tac(Fv)-PE38
Humanized AntiTac Toxin
Immunotoxin LMB-2
LMB-2
LMB-2 (Anti-TAC(FV)-PE-38)
LMB-2 Immunotoxin
LMB-2 immunotoxin

External Source Codes: 
NSC Code 676422 (see NCI DTP info)
PDQ Closed Trial Search ID 43377
PDQ Open Trial Search ID 43377 (check for NCI PDQ open clinical trial info)
UMLS CUI C0655013

Other Properties:
Name Value (qualifiers indented underneath)
code C2513
Contributing_Source CTRP
Legacy_Concept_Name LMB-2_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2513

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