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Version: 17.06d (Release date: 2017-06-26)
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Hu14.18-IL2 Fusion Protein (Code C2509)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Hu14.18-IL2 Fusion Protein

Definition: A recombinant protein consisting of the hu14.18 monoclonal antibody fused to the cytokine interleukin-2 (IL2) with potential antineoplastic activity. The monoclonal antibody portion of the hu14.18-IL2 fusion protein binds to tumor cells expressing the GD2 antigen (melanoma, neuroblastoma and certain other tumors); the Fc component of the fusion protein antibody moiety and natural killer (NK) cells mediate antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cellular cytotoxicity (CDCC) towards GD2-expressing tumor cells. The localized IL2 moiety of the fusion protein stimulates NK and T-cell antitumor cellular immune responses.

NCI-GLOSS Definition: An anticancer drug in which hu14.18, a monoclonal antibody, is combined with interleukin-2. The monoclonal antibody binds to the cancer cells and delivers IL-2, which stimulates the immune system to destroy the cancer cells.

Display Name: Hu14.18-IL2 Fusion Protein

Label: Hu14.18-IL2 Fusion Protein

NCI Thesaurus Code: C2509 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1529682  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EMD 273063
Hu14.18-IL2
Hu14.18-IL2 Fusion Protein
hu14.18-interleukin-2 fusion protein
Hu 14.18/IL - 2 Fusion Protein

External Source Codes: 
NSC Code 721298 (see NCI DTP info)
PDQ Closed Trial Search ID 43349
PDQ Open Trial Search ID 43349 (check for NCI PDQ open clinical trial info)
UMLS CUI C1529682

Other Properties:
     Name Value (qualifiers indented underneath)
code C2509
Contributing_Source CTRP
Legacy_Concept_Name Hu14_18-Interleukin-2_Fusion_Protein
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2509

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