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Version: 17.06d (Release date: 2017-06-26)
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MKC-1 (Code C2507)

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Terms & Properties

Preferred Name: MKC-1

Definition: An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It may prevent cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors.

Display Name: MKC-1

Label: MKC-1

NCI Thesaurus Code: C2507 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796487  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ro 31-7453

External Source Codes: 
CAS Registry Number 125313-92-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 486351
PDQ Open Trial Search ID 486351 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796487

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H16N4O4
code C2507
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ro_31-7453
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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