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Version: 17.06d (Release date: 2017-06-26)
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MKC-1 (Code C2507)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: MKC-1

Definition: An orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus.

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It may prevent cancer cells from dividing. It belongs to the family of drugs called cell cycle inhibitors.

Display Name: MKC-1

Label: MKC-1

NCI Thesaurus Code: C2507 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796487  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MKC-1
R440
Ro 31-7453

External Source Codes: 
CAS Registry Number 125313-92-0 (see NLM ChemIDplus info)
FDA UNII Code DNZ11VPY7Q
PDQ Closed Trial Search ID 486351
PDQ Open Trial Search ID 486351 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796487

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C22H16N4O4
code C2507
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Ro_31-7453
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2507

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