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Version: 17.06d (Release date: 2017-06-26)
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Cisplatin Liposomal (Code C2502)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cisplatin Liposomal

Definition: A synthetic formulation in which the antineoplastic agent cisplatin is encapsulated in lipids. Cisplatin liposomal consists of small aggregates of cisplatin covered by a single lipid bilayer. Encasement in liposomes improves cisplatin's tumor bioavailability and toxicity profile. Liposomal encapsulation does not affect the pharmacological properties of cisplatin directly. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. (NCI04)

Label: Cisplatin Liposomal

NCI Thesaurus Code: C2502 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0964924  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cisplatin, Liposomal
Cisplatin Liposomal
Liposomal Cisplatin
SPI-077
SPI-77
STEALTH Cisplatin
STEALTH Liposomal Cisplatin
STEALTH Liposomal Encapsulated Cisplatin
STEALTH Liposome Cisplatin

External Source Codes: 
NSC Code 719334 (see NCI DTP info)
PDQ Closed Trial Search ID 43292
PDQ Open Trial Search ID 43292 (check for NCI PDQ open clinical trial info)
UMLS CUI C0964924

Other Properties:
     Name Value (qualifiers indented underneath)
code C2502
Legacy_Concept_Name Cisplatin_Liposomal
Semantic_Type Inorganic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2502

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