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Version: 17.06d (Release date: 2017-06-26)
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LMB-1 Immunotoxin (Code C2499)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: LMB-1 Immunotoxin

Definition: A chimeric protein consisting of the Fv portion of a monoclonal antibody attached to a fragment of Pseudomonas exotoxin A without its cell-binding region. LMB-1 immunotoxin targets B3, a Lewis Y-related carbohydrate epitope found on some solid tumors. The antibody attaches to the tumor cell and the exotoxin stops protein synthesis by inactivating elongation factor 2. (NCI04)

NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.

Label: LMB-1 Immunotoxin

NCI Thesaurus Code: C2499 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796420  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B3-NLysPE38
Immunotoxin LMB-1
LMB-1
LMB-1 Immunotoxin
LMB-1 immunotoxin

External Source Codes: 
NSC Code 651311 (see NCI DTP info)
PDQ Closed Trial Search ID 43265
PDQ Open Trial Search ID 43265 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796420

Other Properties:
     Name Value (qualifiers indented underneath)
code C2499
Legacy_Concept_Name LMB-1_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2499

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