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Version: 17.06d (Release date: 2017-06-26)
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Indium In 111-DOTA-Biotin (Code C2495)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Indium In 111-DOTA-Biotin

Definition: A radioconjugate of biotin conjugated with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic acid (DOTA) and labeled with indium In 111 (In-111). Biotin is a water-soluble B-complex vitamin, present in minute amounts in every living cell, while its level in cancerous tissue is higher than that of normal tissue. In 111-DOTA-Biotin could be used in 3-step pre-targeting radioimmunotherapy that employs tumor targeting antibody conjugated with streptavidin, the natural ligand of biotin.

Label: Indium In 111-DOTA-Biotin

NCI Thesaurus Code: C2495 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1512685  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Indium In 111-DOTA-Biotin
In 111-DOTA-Biotin

External Source Codes: 
PDQ Closed Trial Search ID 43232
PDQ Open Trial Search ID 43232 (check for NCI PDQ open clinical trial info)
UMLS CUI C1512685

Other Properties:
     Name Value (qualifiers indented underneath)
code C2495
Legacy_Concept_Name In_111-DOTA-Biotin
Semantic_Type Indicator, Reagent, or Diagnostic Aid

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2495

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