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Version: 16.11d (Release date: 2016-11-28)
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Pegylated Interferon Alfa (Code C2491)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Pegylated Interferon Alfa

Definition: A covalent conjugate of recombinant interferon alpha and polyethylene glycol (PEG), used as an antiviral and antineoplastic agent. The biological activity of this agent is derived from its interferon alpha protein moiety. Interferons alfa bind to specific cell-surface receptors, leading to the transcription and translation of genes whose protein products mediate antiviral, antiproliferative, anticancer, and immune-modulating effects. The PEG moiety lowers the clearance of interferon alpha, thereby extending the duration of its therapeutic effects, but may also reduce interferon-mediated stimulation of an immune response. (NCI04)

Display Name: Pegylated Interferon Alfa

Label: Pegylated Interferon Alfa

NCI Thesaurus Code: C2491 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0907160  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PEG-IFN-a
PEG-interferon alfa
Pegylated Interferon Alfa

External Source Codes: 
PDQ Closed Trial Search ID 43151
PDQ Open Trial Search ID 43151 (check for NCI PDQ open clinical trial info)
UMLS CUI C0907160

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hepatitis C.
code C2491
Contributing_Source CTRP
Legacy_Concept_Name Pegylated_Interferon_Alfa
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2491

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