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Version: 17.06d (Release date: 2017-06-26)
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Polifeprosan 20 with Carmustine Implant (Code C2487)

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Terms & Properties

Preferred Name: Polifeprosan 20 with Carmustine Implant

Definition: A synthetic, biodegradable wafer containing the agent carmustine with antineoplastic activity. Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a biodegradable poly-anhydride copolymer and contains the nitrosourea carmustine. As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Carmustine also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)

NCI-GLOSS Definition: A biodegradable wafer that is used to deliver the anticancer drug carmustine directly into a brain tumor site after the tumor has been removed by surgery.

Display Name: Polifeprosan 20 with Carmustine Implant

Label: Polifeprosan 20 with Carmustine Implant

NCI Thesaurus Code: C2487 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0720676  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carmustine Copolymer
Gliadel Wafer
polifeprosan 20 carmustine implant
Polifeprosan 20 with Carmustine Implant

External Source Codes: 
NSC Code 714372 (see NCI DTP info)
PDQ Closed Trial Search ID 43142
PDQ Open Trial Search ID 43142 (check for NCI PDQ open clinical trial info)
UMLS CUI C0720676

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Malignant glioma, adjuvant to surgery and radiation; Recurrent glioblastoma multiforme, adjuvant to surgery
code C2487
Contributing_Source CTRP
Legacy_Concept_Name Polifeprosan_20_with_Carmustine_Implant
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2487

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