|LMB-9 Immunotoxin (Code C2472)|
|Terms & Properties|
Preferred Name: LMB-9 Immunotoxin
Definition: A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.
NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.
Label: LMB-9 Immunotoxin
NCI Metathesaurus Link: C0678023 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|NSC Code||691236 (see NCI DTP info)|
|PDQ Closed Trial Search ID||43018|
|PDQ Open Trial Search ID||43018 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Semantic_Type||Amino Acid, Peptide, or Protein|
Additional Concept Data:
|Defined Fully by Roles: No|