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Version: 17.06d (Release date: 2017-06-26)
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LMB-9 Immunotoxin (Code C2472)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: LMB-9 Immunotoxin

Definition: A recombinant disulfide stabilized anti-Lewis Y IgG immunotoxin containing a 38 KD toxic element derived from the Pseudomonas aeruginosa exotoxin A and a monoclonal antibody fragment, designed to target adenocarcinomas expressing Lewis Y. LMB-9 immunotoxin attaches to tumor cells, facilitating he entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis.

NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.

Label: LMB-9 Immunotoxin

NCI Thesaurus Code: C2472 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0678023  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B3 (dsFv)-PE38
Immunotoxin LMB-9
LMB-9
LMB-9 Immunotoxin
LMB-9 immunotoxin

External Source Codes: 
NSC Code 691236 (see NCI DTP info)
PDQ Closed Trial Search ID 43018
PDQ Open Trial Search ID 43018 (check for NCI PDQ open clinical trial info)
UMLS CUI C0678023

Other Properties:
     Name Value (qualifiers indented underneath)
code C2472
Legacy_Concept_Name LMB-9_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2472

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