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National Cancer Institute
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Version: 16.10e (Release date: 2016-10-31)
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Ad5CMV-p53 Gene (Code C2471)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Ad5CMV-p53 Gene

Definition: A replication-defective adenoviral-CMV vector that encodes a wild-type p53 gene. Ad5CMV-p53 induces tumor cells that have been transfected with the vector to produce wild-type p53, a tumor suppressor gene that is deleted or mutated in a significant number of cancers. In transfected tumor cells, the wild-type p-53 gene product exerts an antitumor effect by blocking cell cycle progression at the G1/S regulation point, activating DNA repair proteins in the presence of DNA damage, and initiating apoptosis when DNA damage is irreparable. (NCI04)

Display Name: Ad5CMV-p53 Gene

Label: Ad5CMV-p53 Gene

NCI Thesaurus Code: C2471 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1135129  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad-p53
Ad5CMV-p53 Gene
Ad5CMV p53 Gene
Adeno-p53
Adenovirus p53
Advexin
INGN-201
p53 Gene, Ad5CMV
RPR/INGN-201

External Source Codes: 
NSC Code 683550 (see NCI DTP info)
PDQ Closed Trial Search ID 43016
PDQ Open Trial Search ID 43016 (check for NCI PDQ open clinical trial info)
UMLS CUI C1135129

Other Properties:
Name Value (qualifiers indented underneath)
code C2471
Contributing_Source CTRP
Legacy_Concept_Name Ad5CMV-p53_Gene
Semantic_Type Pharmacologic Substance
Semantic_Type Virus

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2471

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