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Version: 16.11d (Release date: 2016-11-28)
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Incyclinide (Code C2454)

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Terms & Properties

Preferred Name: Incyclinide

Definition: A chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. COL-3 may block the growth of new blood vessels that tumors need to grow. It is a type of matrix metalloproteinase inhibitor and a type of antiangiogenesis agent.

Display Name: Incyclinide

Label: Incyclinide

NCI Thesaurus Code: C2454 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0763138  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-dedimethylamino sancycline
4-Dimethlyaminosancycline
4-Dimethlyamino Sancycline
6-deoxy, 6-demethyl, 4-de-dimethylamino tetracycline
6-deoxy-6-demethyl-4-dedimethylaminotetracycline
CMT-3
COL-3
COL 3
Incyclinide
INCYCLINIDE
Metastat
Tetracycline CMT-3

External Source Codes: 
CAS Registry Number 15866-90-7 (see NLM ChemIDplus info)
FDA UNII Code 21G64WZQ4I
NSC Code 683551 (see NCI DTP info)
PDQ Closed Trial Search ID 42884
PDQ Open Trial Search ID 42884 (check for NCI PDQ open clinical trial info)
UMLS CUI C0763138

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C19H17NO7
code C2454
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name COL-3
Semantic_Type Antibiotic
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2454

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