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National Cancer Institute
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Version: 17.08d (Release date: 2017-08-28)
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ERB-38 Immunotoxin (Code C2453)

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Terms & Properties

Preferred Name: ERB-38 Immunotoxin

Definition: A bivalent fusion protein consisting of disulfide-stabilized Fv fragments of an anti-HER2 (erbB2) monoclonal antibody (e23) and a truncated version of the M(r) 38 fragment of Pseudomonas exotoxin that lacks the toxin's cell binding domain. ERB-38 immunotoxin binds specifically to cells that overexpress HER2, the antigenic target of the monoclonal antibody; the exotoxin portion of the immunotoxin then lyses the cells bound by the antibody portion. (NCI04)

NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.

Label: ERB-38 Immunotoxin

NCI Thesaurus Code: C2453 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0677808  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
erb-38 immunotoxin
ERB-38 Immunotoxin

External Source Codes: 
NSC Code 683039 (see NCI DTP info)
PDQ Closed Trial Search ID 42875
PDQ Open Trial Search ID 42875 (check for NCI PDQ open clinical trial info)
UMLS CUI C0677808

Other Properties:
     Name Value (qualifiers indented underneath)
code C2453
Legacy_Concept_Name ERB-38_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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