skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.11d (Release date: 2016-11-28)
SearchBox Top
SearchBox Bottom
Sargramostim Plasmid DNA Pancreatic Tumor Cell Vaccine (Code C2445)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Sargramostim Plasmid DNA Pancreatic Tumor Cell Vaccine

Definition: A whole cell vaccine comprised of irradiated allogenic pancreatic tumor cells transfected with a plasmid DNA encoding human sargramostim (GM-CSF). Vaccination results in expression of GM-CSF, which induces proliferation and differentiation of hematopoietic lineage cells as well as stimulating macrophage and dendritic cell functions in antigen presentation and antitumor cell-mediated immunity. Furthermore, administration of this pancreatic tumor cell vaccine may elicit a cytotoxic T lymphocyte (CTL) response against similar host tumor cells, resulting in decreased tumor growth.

Display Name: Sargramostim Plasmid DNA Pancreatic Tumor Cell Vaccine

Label: Sargramostim Plasmid DNA Pancreatic Tumor Cell Vaccine

NCI Thesaurus Code: C2445 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0677758  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GM-CSF plasmid DNA pancreatic tumor cell vaccine
Sargramostim Plasmid DNA Pancreatic Tumor Cell Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 42810
PDQ Open Trial Search ID 42810 (check for NCI PDQ open clinical trial info)
UMLS CUI C0677758

Other Properties:
Name Value (qualifiers indented underneath)
code C2445
Contributing_Source CTRP
Legacy_Concept_Name Sargramostim_Plasmid_DNA_Pancreatic_Tumor_Cell_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2445

Mainbox Bottom