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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 131 Tositumomab (Code C2444)

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Terms & Properties

Preferred Name: Iodine I 131 Tositumomab

Definition: A monoclonal antibody directed against the CD20 protein expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope iodine I 131 with potential antineoplastic activity. Iodine I 131 tositumomab binds to and selectively delivers cyctotoxic radiation to CD20-expressing B-lymphocytes, thereby minimizing systemic radiotoxicity.

NCI-GLOSS Definition: A monoclonal antibody (tositumomab) that has been chemically changed by adding radioactive iodine, and that is used in the treatment of certain types of non-Hodgkin lymphoma. It belongs to the family of drugs called radioconjugated monoclonal antibodies. When iodine I 131 tositumomab and tositumomab are given together, the combination is called the Bexxar regimen.

Display Name: Iodine I 131 Tositumomab

Label: Iodine I 131 Tositumomab

NCI Thesaurus Code: C2444 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0768182  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
131-I-Anti-B1 Monoclonal Antibody
I131-MOAB-B1
Iodine-131 Anti-B1 Antibody
Iodine-131 Anti-CD20 Monoclonal Antibody
Iodine-131 Tositumomab
Iodine I 131 MOAB Anti-B1
Iodine I 131 Monoclonal Antibody Anti-B1
Iodine I 131 Tositumomab
iodine I 131 tositumomab
I 131 Monoclonal Antibody Anti-B1
I 131 Tositumomab
TOSITUMOMAB I-131

External Source Codes: 
CAS Registry Number 192391-48-3 (see NLM ChemIDplus info)
FDA UNII Code K1KT5M40JC
NSC Code 715813 (see NCI DTP info)
PDQ Closed Trial Search ID 42806
PDQ Open Trial Search ID 42806 (check for NCI PDQ open clinical trial info)
UMLS CUI C0768182

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For CD-20-antigen-expressing, relapsed or refractory, low-grade, follicular, or transformed Non-Hodgkins lymphoma
code C2444
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name I_131_Monoclonal_Antibody_Anti-B1
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2444

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