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Version: 17.06d (Release date: 2017-06-26)
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Canarypox-hIL-12 Melanoma Vaccine (Code C2442)

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Terms & Properties

Preferred Name: Canarypox-hIL-12 Melanoma Vaccine

Definition: A vaccine consisting of a replication-defective recombinant canarypox virus (ALVAC) that encodes the gene for human interleukin-12 (hIL-12). Produced mainly by B-cells, IL-12 is an endogenous cytokine that activates natural killer (NK) cells, promotes cytotoxic T lymphocyte (CTL) responses, induces the release of interferon-gamma (IFN-gamma), and may exhibit antitumor and anti-angiogenic effects. Vaccination with canarypox-hIL-12 melanoma vaccine may stimulate the host immune system to mount an immune response against tumor cells, thereby inhibiting tumor growth and/or metastasis. (NCI04)

Label: Canarypox-hIL-12 Melanoma Vaccine

NCI Thesaurus Code: C2442 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0677735  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALVAC-hIL-12
ALVAC-hIL-12 melanoma vaccine
Canarypox-hIL-12 Melanoma Vaccine

External Source Codes: 
NSC Code 689514 (see NCI DTP info)
PDQ Closed Trial Search ID 42766
PDQ Open Trial Search ID 42766 (check for NCI PDQ open clinical trial info)
UMLS CUI C0677735

Other Properties:
     Name Value (qualifiers indented underneath)
code C2442
Legacy_Concept_Name Canarypox-hIL-12_Melanoma_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2442

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