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Version: 17.06d (Release date: 2017-06-26)
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IL-2 Plasmid DNA/Lipid Complex (Code C2437)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: IL-2 Plasmid DNA/Lipid Complex

Definition: An immunotherapeutic agent consisting of a plasmid DNA encoding human Interleukin-2 (IL-2) complexed with a cationic lipid, 1,2-dimyristyloxypropyl-3-dimethyl-hydroxyethyl ammonium bromide/dioleyl-phosphatidyl-ethanolamine (DMRIE/DOPE), in a 5:1 ratio. Due to the lipophilic nature of this cation liposome complex, this gene transfer system may improve the efficiency of introducing the IL-2 gene into the cells, thereby increasing the production of IL-2 and inducing an immune response.

NCI-GLOSS Definition: An agent that delivers the gene for interleukin-2 (IL-2) into cells to increase production of IL-2 by the cells.

Label: IL-2 Plasmid DNA/Lipid Complex

NCI Thesaurus Code: C2437 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0677671  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IL-2 Plasmid DNA/DMRIE/DOPE lipid complex
IL-2 Plasmid DNA/Lipid Complex
interleukin-2 DNA/lipid complex
leuvectin
Leuvectin
Plasmid DNA IL-2 Lipid Complex
VCL-1102

External Source Codes: 
PDQ Closed Trial Search ID 42699
PDQ Open Trial Search ID 42699 (check for NCI PDQ open clinical trial info)
UMLS CUI C0677671

Other Properties:
     Name Value (qualifiers indented underneath)
code C2437
Legacy_Concept_Name IL-2_Plasmid_DNA-Lipid_Complex
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2437

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