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Version: 17.06d (Release date: 2017-06-26)
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Vitespen (Code C2432)

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Terms & Properties

Preferred Name: Vitespen

Definition: An autologous cancer vaccine derived from tumor-specific gp96 heat shock proteins. Heat shock proteins chaperone peptides through the endoplasmic reticulum, are key regulators of dendritic cell maturation, migration and antigen processing, and are involved in T-cell activation. (NCI04)

NCI-GLOSS Definition: A vaccine made from a patient's tumor cells that may help the body's immune system kill cancer cells. This vaccine is used to treat kidney cancer, a type of brain cancer called glioma, and metastatic melanoma (a type of skin cancer that has spread). It is also being studied in the treatment of other types of cancer.

Display Name: Vitespen

Label: Vitespen

NCI Thesaurus Code: C2432 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0935952  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Autologous gp96 Heat Shock Protein Peptide Complex Vaccine
gp96 Heat Shock Protein-Peptide Complex
gp96 heat shock protein-peptide complex vaccine
gp96 HSP-Peptide Complex
gp96 HSP-peptide complex
Heat Shock Protein Peptide Complex-96
HSPPC-96
HSP gp96-Peptide Complex
Oncophage
Recombinant Human Tumor Rejection Antigen 1
Vitespen
VITESPEN
vitespen

External Source Codes: 
CAS Registry Number 492448-75-6 (see NLM ChemIDplus info)
FDA UNII Code H3598Y1TLJ
NSC Code 725085 (see NCI DTP info)
PDQ Closed Trial Search ID 42682
PDQ Open Trial Search ID 42682 (check for NCI PDQ open clinical trial info)
UMLS CUI C0935952

Other Properties:
     Name Value (qualifiers indented underneath)
code C2432
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Autologous_gp96_Heat_Shock_Protein_Peptide_Complex_Vaccine
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2432

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