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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Adenovirus-p53 SCH-58500 (Code C2423)

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Terms & Properties

Preferred Name: Recombinant Adenovirus-p53 SCH-58500

Definition: A genetically-engineered adenovirus that contains the gene that encodes the human tumor-suppressor protein p53 with potential antineoplastic activity. Recombinant adenovirus-p53 SCH-58500 delivers p53 into tumor cells, which may result in p53-mediated cell cycle arrest and apoptosis.

NCI-GLOSS Definition: A substance that has been studied in the treatment of some types of cancer. rAd/p53 is a weakened adenovirus that carries the p53 gene into tumor cells, causing them to die. It is a type of gene therapy.

Label: Recombinant Adenovirus-p53 SCH-58500

NCI Thesaurus Code: C2423 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1514767  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ACN53
rAd/p53
recombinant adenovirus-p53
Recombinant Adenovirus-p53 SCH-58500
SCH-58500
SCH 58500

External Source Codes: 
PDQ Closed Trial Search ID 42631
PDQ Open Trial Search ID 42631 (check for NCI PDQ open clinical trial info)
UMLS CUI C1514767

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Primary ovarian cancer
code C2423
Legacy_Concept_Name Recombinant_Adenovirus-p53
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2423

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