skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Gimeracil (Code C2416)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Gimeracil

Definition: A pyridine derivative with antitumor activity. Gimeracil enhances the antitumor activity of fluoropyrimidines by competitively and reversibly inhibiting the enzyme dihydropyrimidine dehydrogenase causing decreased degradation of the fluoropyrimidines.

Label: Gimeracil

NCI Thesaurus Code: C2416 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0535459  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-Chloro-2,4-pyridinediol
CDHP
Chlorodihydroxypyridine
GIMERACIL
Gimeracil

External Source Codes: 
CAS Registry Number 103766-25-2 (see NLM ChemIDplus info)
FDA UNII Code UA8SE1325T
PDQ Closed Trial Search ID 42587
PDQ Open Trial Search ID 42587 (check for NCI PDQ open clinical trial info)
UMLS CUI C0535459

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C5H4ClNO2
code C2416
Contributing_Source FDA
Legacy_Concept_Name Chlorodihydroxypyridine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2416

Mainbox Bottom