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Version: 17.06d (Release date: 2017-06-26)
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T4N5 Liposomal Lotion (Code C2408)

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Terms & Properties

Preferred Name: T4N5 Liposomal Lotion

Definition: A topical lotion that contains the enzyme T4-bacteriophage endonuclease V encapsulated within liposomes. With topical liposomal delivery, the DNA repair enzyme T4-bacteriophage endonuclease V is transported into skin cells, where the enzyme enters cell nuclei and binds to and incises pyrimidine dimers, thereby catalyzing the first reaction step of the cellular excision repair pathway for removing DNA replication-inhibiting pyrimidine dimers produced within duplex DNA through exposure to ultraviolet (UV) irradiation. In vitro and in vivo studies indicate that T4N5 liposomes increases repair of DNA damage caused by UV irradiation. (NCI05)

NCI-GLOSS Definition: A lotion being studied in the treatment of skin cancer and a skin condition called xeroderma pigmentosum. It has an enzyme contained in very tiny, fat-like particles. The enzyme repairs damage caused by ultraviolet radiation. T4N5 liposomal lotion is a type of DNA repair enzyme topical agent.

Display Name: T4N5 Liposomal Lotion

Label: T4N5 Liposomal Lotion

NCI Thesaurus Code: C2408 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1710278  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Bacteriophage T4 Endonuclease V in Liposomal Lotion
Lotion, T4N5 Liposomal
T4N5 Liposomal Lotion
T4N5 liposomal lotion
T4 Endonuclease V Liposomal Lotion

External Source Codes: 
PDQ Closed Trial Search ID 42482
PDQ Open Trial Search ID 42482 (check for NCI PDQ open clinical trial info)
UMLS CUI C1710278

Other Properties:
     Name Value (qualifiers indented underneath)
code C2408
Contributing_Source CTRP
Legacy_Concept_Name T4N5_Liposomal_Lotion
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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