|Boronophenylalanine-Fructose Complex (Code C2405)|
|Terms & Properties|
Preferred Name: Boronophenylalanine-Fructose Complex
Definition: A boronated phenylalanine complexed with fructose to increase its solubility. When exposed to neutron irradiation, boronophenylalanine absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues.
NCI-GLOSS Definition: A substance used in a type of radiation therapy called boron neutron capture therapy. BPA-F is injected into a vein, and becomes concentrated in tumor cells. The patient then receives radiation treatment with atomic particles called neutrons. The neutrons react with the boron in BPA-F, producing radioactive particles that kill the tumor cells without harming normal cells.
Label: Boronophenylalanine-Fructose Complex
NCI Metathesaurus Link: C0289335 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|PDQ Closed Trial Search ID||42404|
|PDQ Open Trial Search ID||42404 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|