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Version: 17.06d (Release date: 2017-06-26)
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Boronophenylalanine-Fructose Complex (Code C2405)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Boronophenylalanine-Fructose Complex

Definition: A boronated phenylalanine complexed with fructose to increase its solubility. When exposed to neutron irradiation, boronophenylalanine absorbs neutrons and self-destructs releasing short-range alpha radiation and 'recoil' lithium in tumor cells, resulting in alpha radiation-induced tumor cell death. This highly selective, localized radiotargeting of tumor cells, known as boron neutron capture therapy (BNCT), spares adjacent normal tissues.

NCI-GLOSS Definition: A substance used in a type of radiation therapy called boron neutron capture therapy. BPA-F is injected into a vein, and becomes concentrated in tumor cells. The patient then receives radiation treatment with atomic particles called neutrons. The neutrons react with the boron in BPA-F, producing radioactive particles that kill the tumor cells without harming normal cells.

Label: Boronophenylalanine-Fructose Complex

NCI Thesaurus Code: C2405 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0289335  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Boronophenylalanine-Fructose Complex
boronophenylalanine-fructose complex
BPA-F
p-Boronophenylalanine-Fructose Complex

External Source Codes: 
PDQ Closed Trial Search ID 42404
PDQ Open Trial Search ID 42404 (check for NCI PDQ open clinical trial info)
UMLS CUI C0289335

Other Properties:
     Name Value (qualifiers indented underneath)
code C2405
Legacy_Concept_Name Boronophenylalanine-Fructose_Complex
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2405

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