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Version: 17.06d (Release date: 2017-06-26)
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Rasburicase (Code C2404)

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Terms & Properties

Preferred Name: Rasburicase

Definition: A recombinant urate oxidase enzyme isolated from a genetically-modified strain of Saccharomyces cerevisiae. Urate oxidase catalyzes the oxidation of uric acid to the excretable metabolite allantoin, a molecule that is 5-10 times more water-soluble than uric acid. An enzyme that occurs endogenously in most mammals, urate oxidase is not found in humans. (NCI04)

NCI-GLOSS Definition: A drug used to treat high blood levels of uric acid in patients with leukemia, lymphoma, and other types of cancer who are receiving certain types of cancer treatment. It is also being studied in the treatment of other medical conditions. Elitek is a type of recombinant enzyme and a type of urate-lowering drug.

Display Name: Rasburicase

Label: Rasburicase

NCI Thesaurus Code: C2404 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0937932  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Urate Oxidase
recombinant urate oxidase
SR 29142
Urate Oxidase

External Source Codes: 
CAS Registry Number 134774-45-1 (see NLM ChemIDplus info)
NSC Code 721631 (see NCI DTP info)
PDQ Closed Trial Search ID 299001
PDQ Open Trial Search ID 299001 (check for NCI PDQ open clinical trial info)
UMLS CUI C0937932

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Chemotherapy-induced acute hyperuricemia, treatment and prophylaxis
code C2404
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Rasburicase
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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