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Version: 17.04d (Release date: 2017-04-24)
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Tretinoin Liposome (Code C2398)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Tretinoin Liposome

Definition: An intravenous formulation of tretinoin (vitamin A acid or all-trans retinoic acid) encased in liposomes. Tretinoin is a naturally occurring retinoic acid agent that binds to and activates retinoic acid receptors (RAR), effecting changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of carcinogenesis. This agent also inhibits telomerase, leading to telomere shortening and eventual apoptosis of certain tumor cell types. Liposome encapsulation extends the half-life of intravenously administered tretinoin.

Label: Tretinoin Liposome

NCI Thesaurus Code: C2398 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0338222  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
All-trans-retinoic acid liposomal
AR-623
Atragen
Liposomal all-trans-retinoic acid
Liposomal tretinoin
TretinoinLF
Tretinoin Liposomal
Tretinoin Liposome

External Source Codes: 
PDQ Closed Trial Search ID 42285
PDQ Open Trial Search ID 42285 (check for NCI PDQ open clinical trial info)
UMLS CUI C0338222

Other Properties:
     Name Value (qualifiers indented underneath)
code C2398
Legacy_Concept_Name Tretinoin_Liposome
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2398

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