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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Cytarabine (Code C2388)

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Terms & Properties

Preferred Name: Liposomal Cytarabine

Definition: A liposomal intrathecal formulation of the antimetabolite cytarabine. As an S-phase-specific antimetabolite, cytarabine is phosphorylated by deoxycytidine kinase to a triphosphate form which competes with thymidine for incorporation into DNA; the incorporation of cytarabine triphosphate into DNA appears to inhibit DNA polymerase and so DNA synthesis, resulting in cell death. (NCI04)

NCI-GLOSS Definition: A form of the anticancer drug cytarabine that is contained inside very tiny, fat-like particles. It may have fewer side effects and work better than cytarabine. It is used to treat lymphoma that has spread to the meninges (three thin layers of tissue that cover and protect the brain and spinal cord). It is also being studied in the treatment of other types of cancer. It is a type of antimetabolite.

Display Name: Liposomal Cytarabine

Label: Liposomal Cytarabine

NCI Thesaurus Code: C2388 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0795597  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cytarabine Liposome
cytarabine liposome
Depo-Cyt
DepoCyt
DepoCyte
DepoFoam Encapsulated Cytarabine
DTC 101
Encapsulated Cytarabine
Liposomal Cytarabine
liposomal cytarabine
Liposomal cytarabine

External Source Codes: 
NSC Code 715320 (see NCI DTP info)
PDQ Closed Trial Search ID 42260
PDQ Open Trial Search ID 42260 (check for NCI PDQ open clinical trial info)
UMLS CUI C0795597

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Lymphomatous meningitis
code C2388
Contributing_Source CTRP
Legacy_Concept_Name Liposomal_Cytarabine
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2388

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