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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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DAB389 Epidermal Growth Factor (Code C2383)

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Terms & Properties

Preferred Name: DAB389 Epidermal Growth Factor

Definition: A recombinant fusion protein composed of the diphtheria toxin with the receptor-binding domain replaced by human epidermal growth factor (EGF). When administered, EGF binds to the endothelial cell growth factor receptor, EGFR, which is upregulated in many solid tumors. After binding to the EGF receptor, the agent is internalized by the cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein synthesis through ADP-ribosylation of elongation factor 2. (NCI04)

Label: DAB389 Epidermal Growth Factor

NCI Thesaurus Code: C2383 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281573  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DAB389 Epidermal Growth Factor

External Source Codes: 
PDQ Closed Trial Search ID 42032
PDQ Open Trial Search ID 42032 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281573

Other Properties:
     Name Value (qualifiers indented underneath)
code C2383
Legacy_Concept_Name DAB389_Epidermal_Growth_Factor
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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