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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Etanercept (Code C2381)

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Terms & Properties

Preferred Name: Etanercept

Definition: A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)

NCI-GLOSS Definition: A drug that is commonly used to treat arthritis. It is also being studied in the treatment of cancer, and as a treatment for loss of appetite and weight loss in cancer patients. It belongs to the family of drugs called tumor necrosis factor (TNF) antagonists.

Display Name: Etanercept

Label: Etanercept

NCI Thesaurus Code: C2381 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0717758  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Tumor Necrosis Factor Receptor IgG Chimera

External Source Codes: 
CAS Registry Number 185243-69-0 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 257809
PDQ Open Trial Search ID 257809 (check for NCI PDQ open clinical trial info)
UMLS CUI C0717758

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For juvenile arthritis; psoriatic arthritis; rheumatoid arthritis.
code C2381
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Etanercept
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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