skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.08d (Release date: 2017-08-28)
SearchBox Top
SearchBox Bottom
L-Leucyl-L-Leucine Methyl Ester (Code C2377)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: L-Leucyl-L-Leucine Methyl Ester

Definition: A 2-amino acid compound with immunomodulatory activity. L-leucyl-L-leucine methyl ester (LLME) is a lysosomotropic agent entering cells via receptor-mediated endocytosis. LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. Condensation of LLME leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T-cells and natural killer cells. Therefore, this agent may be able to decrease the incidence of graft versus host disease (GVHD) via cytotoxic T-cell depletion. Furthermore, LLME has the potential in augmenting antibody production when used in pretreatment of peripheral blood mononuclear cells (PBMCs), possibly via interfering gene expressions of inflammatory factors.

Label: L-Leucyl-L-Leucine Methyl Ester

NCI Thesaurus Code: C2377 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0281255  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
L-Leucyl-L-Leucine Methyl Ester

External Source Codes: 
CAS Registry Number 13022-42-9 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 41645
PDQ Open Trial Search ID 41645 (check for NCI PDQ open clinical trial info)
UMLS CUI C0281255

Other Properties:
     Name Value (qualifiers indented underneath)
code C2377
Legacy_Concept_Name L-Leucyl-L-Leucine_Methyl_Ester
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


Mainbox Bottom