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Version: 17.06d (Release date: 2017-06-26)
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Amoxicillin (Code C237)

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Terms & Properties

Preferred Name: Amoxicillin

Definition: A broad-spectrum, semisynthetic aminopenicillin antibiotic with bactericidal activity. Amoxicillin binds to and inactivates penicillin-binding protein (PBP) 1A located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity. This interrupts bacterial cell wall synthesis and results in the weakening of the bacterial cell wall and causes cell lysis.

NCI-GLOSS Definition: A drug used to treat some bacterial infections. Amoxicillin is a form of penicillin that is made in the laboratory. It kills certain types of bacteria. It is a type of antibiotic.

Label: Amoxicillin

NCI Thesaurus Code: C237 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0002645  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AMOX
amoxicillin
AMOXICILLIN
Amoxicillin
Amoxicillin Trihydrate
Amoxil
Polymox
Trimox
Utimox
Wymox

External Source Codes: 
CAS Registry Number 61336-70-7 (see NLM ChemIDplus info)
FDA UNII Code 804826J2HU
ChEBI ID CHEBI:51254 (see ChEBI info)
NSC Code 277174 (see NCI DTP info)
PDQ Closed Trial Search ID 42310
PDQ Open Trial Search ID 42310 (check for NCI PDQ open clinical trial info)
UMLS CUI C0002645

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C16H19N3O5S.3H2O
code C237
Contributing_Source FDA
Legacy_Concept_Name Amoxicillin
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C237

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