skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 16.12d (Release date: 2016-12-27)
SearchBox Top
SearchBox Bottom
CB10-277 (Code C2367)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: CB10-277

Definition: A synthetic derivative of dimethylphenyl-triazene related to dacarbazine, with antineoplastic properties. Related to the agent dacarbazine, CB10-277 is converted in vivo to a monomethyl triazene form that alkylates DNA, resulting in inhibition of DNA replication and repair; in addition, this agent may act as a purine analogue, resulting in inhibition of DNA synthesis, and may interact with protein sulfhydryl groups. (NCI04)

Label: CB10-277

NCI Thesaurus Code: C2367 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0088835  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1-p-carboxy-3,3-dimethylphenyltriazine
CB10-277

External Source Codes: 
NSC Code 208107 (see NCI DTP info)
PDQ Closed Trial Search ID 41154
PDQ Open Trial Search ID 41154 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference phase II trial shown to be inactive; http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2394365/ (see PubMed Primary Reference info)
UMLS CUI C0088835

Other Properties:
Name Value (qualifiers indented underneath)
code C2367
Legacy_Concept_Name CB10-277
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2367

Mainbox Bottom