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Version: 17.06d (Release date: 2017-06-26)
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M-Azidopyrimethamine (Code C2366)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: M-Azidopyrimethamine

Definition: An antifolate derived from diaminopyrimidine with cytotoxic properties. With a mechanism of action similar to that of methotrexate (MTX), m-azidopyrimethamine blocks tetrahydrofolate synthesis, resulting in depletion of nucleotide precursors and inhibition of DNA, RNA and protein synthesis. This agent is more lipophilic but less potent than MTX. (NCI04)

Label: M-Azidopyrimethamine

NCI Thesaurus Code: C2366 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0280485  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
M-Azidopyrimethamine
MZP

External Source Codes: 
NSC Code 382050 (see NCI DTP info)
PDQ Closed Trial Search ID 40860
PDQ Open Trial Search ID 40860 (check for NCI PDQ open clinical trial info)
UMLS CUI C0280485

Other Properties:
     Name Value (qualifiers indented underneath)
code C2366
Legacy_Concept_Name M-Azidopyrimethamine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2366

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