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Version: 17.06d (Release date: 2017-06-26)
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Timonacic (Code C2354)

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Terms & Properties

Preferred Name: Timonacic

Definition: A cyclic sulfur amino acid derivative with potential antineoplastic and antioxidant activities. Acting on cellular membranes of malignant cells through an unknown mechanism, timonacic may induce malignant cells to revert back to an untransformed state. This agent may also restore contact inhibition, a phenomenon characterized by the paracrine inhibition of mitosis following the formation of a critical cell mass, presumably the result of cell-to-cell signal transfer. Timonacic may also produce antioxidant effects secondary to its release of cysteine and restoration of glutathione concentrations.

Label: Timonacic

NCI Thesaurus Code: C2354 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0076425  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Thiazolidinecarboxylic Acid
4-Thiazolidine Carboxylic Acid
ATC
Detoxepa
Hepalidine
Heparegen
Thiaproline
Thiazolidine-4-carboxylic acid
Thiazolidine-4-carboxylic Acid
Thiazolidinecarboxylic Acid
Thiazolidine Carboxylic Acid
Thioproline
Tiazolidin
Timonacic
TIMONACIC

External Source Codes: 
CAS Registry Number 444-27-9 (see NLM ChemIDplus info)
FDA UNII Code E5913T3IBL
ChEBI ID CHEBI:64564 (see ChEBI info)
NSC Code 25855 (see NCI DTP info)
PDQ Closed Trial Search ID 39714
PDQ Open Trial Search ID 39714 (check for NCI PDQ open clinical trial info)
UMLS CUI C0076425

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C4H7NO2S
code C2354
Contributing_Source FDA
Legacy_Concept_Name Thiazolidine_Carboxylic_Acid
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2354

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