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Version: 17.12d (Release date: 2017-12-26)
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Recombinant Soluble Human CD4 Protein (Code C2342)

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Terms & Properties

Preferred Name: Recombinant Soluble Human CD4 Protein

Definition: A recombinant human soluble CD4 with antiviral activity. Recombinant human soluble CD4 has the amino terminus but not the T-cell binding domain of the endogenous CD4 antigen. This soluble CD4 protein competitively binds to envelope glycoprotein (gp120) of human immunodeficiency virus (HIV) resulting in inhibition of interaction between gp120 and the endogenous CD4 antigen, thereby blocking viral recognition of CD4 and subsequent entry of HIV into CD4 bearing cells.

Label: Recombinant Soluble Human CD4 Protein

NCI Thesaurus Code: C2342 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0279074  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Recombinant Soluble Human CD4 Protein

External Source Codes: 
PDQ Closed Trial Search ID 39062
PDQ Open Trial Search ID 39062 (check for NCI PDQ open clinical trial info)
UMLS CUI C0279074

Other Properties:
     Name Value (qualifiers indented underneath)
code C2342
Legacy_Concept_Name Recombinant_Soluble_Human_CD4_Protein
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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