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Version: 17.06d (Release date: 2017-06-26)
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B43-PAP Immunotoxin (Code C2331)

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Terms & Properties

Preferred Name: B43-PAP Immunotoxin

Definition: A mouse-derived anti-human CD19 monoclonal antibody linked to pokeweed (Phytolacca americana) antiviral protein (PAP) with antileukemic activity. The monoclonal antibody portion specifically binds to the CD19 antigen, a cell surface molecule normally expressed only by B lymphocytes and follicular dendritic cells, while over-expressed in B-lineage lymphocytic leukemia cells. Following internalization, PAP, a plant hemitoxin and a ribosome-inactivating protein, is cleaved from the immunoconjugate and released into the cytoplasm where it enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of rRNA leading to inhibition of protein synthesis and cell growth, but not necessarily cell death.

NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.

Label: B43-PAP Immunotoxin

NCI Thesaurus Code: C2331 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0796424  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
B43-PAP Immunotoxin
B43-PAP immunotoxin
B43-Pokeweed Antiviral Protein Immunotoxin
B43 Immunotoxin

External Source Codes: 
PDQ Closed Trial Search ID 43266
PDQ Open Trial Search ID 43266 (check for NCI PDQ open clinical trial info)
UMLS CUI C0796424

Other Properties:
     Name Value (qualifiers indented underneath)
code C2331
Legacy_Concept_Name B43-PAP_Immunotoxin
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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