|B43-PAP Immunotoxin (Code C2331)|
|Terms & Properties|
Preferred Name: B43-PAP Immunotoxin
Definition: A mouse-derived anti-human CD19 monoclonal antibody linked to pokeweed (Phytolacca americana) antiviral protein (PAP) with antileukemic activity. The monoclonal antibody portion specifically binds to the CD19 antigen, a cell surface molecule normally expressed only by B lymphocytes and follicular dendritic cells, while over-expressed in B-lineage lymphocytic leukemia cells. Following internalization, PAP, a plant hemitoxin and a ribosome-inactivating protein, is cleaved from the immunoconjugate and released into the cytoplasm where it enzymatically removes a single adenine base from a conserved, surface exposed loop sequence of rRNA leading to inhibition of protein synthesis and cell growth, but not necessarily cell death.
NCI-GLOSS Definition: A toxic substance linked to an antibody that attaches to tumor cells and kills them.
Label: B43-PAP Immunotoxin
NCI Metathesaurus Link: C0796424 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
|B43-Pokeweed Antiviral Protein Immunotoxin|
External Source Codes:
|PDQ Closed Trial Search ID||43266|
|PDQ Open Trial Search ID||43266 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
|Semantic_Type||Amino Acid, Peptide, or Protein|
Additional Concept Data:
|Defined Fully by Roles: No|