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Version: 17.10e (Release date: 2017-10-30)
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Niacinamide (Code C2327)

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Terms & Properties

Preferred Name: Niacinamide

Definition: The active form of vitamin B3 and a component of the coenzyme nicotinamide adenine dinucleotide (NAD). Niacinamide acts as a chemo- and radio-sensitizing agent by enhancing tumor blood flow, thereby reducing tumor hypoxia. This agent also inhibits poly(ADP-ribose) polymerases, enzymes involved in the rejoining of DNA strand breaks induced by radiation or chemotherapy.

NCI-GLOSS Definition: A nutrient in the vitamin B complex that the body needs in small amounts to function and stay healthy. Niacinamide helps some enzymes make energy in the cell. It is found in many plant and animal products. It is water-soluble (can dissolve in water) and must be taken in daily. It is being studied to increase the effect of radiation therapy on tumor cells.

Display Name: Niacinamide

Label: Niacinamide

NCI Thesaurus Code: C2327 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0028027  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Nicotinic Acid Amide
Nicotinic acid amide
Pellagra-Preventing Factor
Vitamin PP

External Source Codes: 
CAS Registry Number 98-92-0 (see NLM ChemIDplus info)
FDA UNII Code 25X51I8RD4
ChEBI ID CHEBI:17154 (see ChEBI info)
NSC Code 27452 (see NCI DTP info)
NSC Code 13128 (see NCI DTP info)
PDQ Closed Trial Search ID 42044
PDQ Open Trial Search ID 42044 (check for NCI PDQ open clinical trial info)
UMLS CUI C0028027

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Pellegra, treatment and prophylaxis; Various dermatologic conditions
Chemical_Formula C6H6N2O
code C2327
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Niacinamide
Semantic_Type Organic Chemical
Semantic_Type Vitamin

Additional Concept Data: 
Defined Fully by Roles: No  


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