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Version: 17.06d (Release date: 2017-06-26)
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Testolactone (Code C2301)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Testolactone

Definition: A progesterone derivative with antineoplastic activity. Testolactone inhibits steroid aromatase, thereby preventing the formation of estrogen from adrenal androstenedione and reducing endogenous estrogen levels. (NCI04)

Label: Testolactone

NCI Thesaurus Code: C2301 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0039600  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,2,3,4,4a,4b,7,9,10,10a-Decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic Acid Delta-Lactone
1-Dehydrotestololactone
13-Hydroxy-3-0x0-13,17-secoandrosta-1,4-dien-17-oic Acid Delta-Lactone
17Alpha-oxo-D-homo-1,4-androstadiene-3,17-dione
D-Homo-17a-oxaandrosta-1,4-diene-3,17-dione
Delta-1-Testololactone
Fludestrin
SQ-9538
SQ 9538
Teslac
TESTOLACTONE
Testolactone
Therapeutic Testolactone

External Source Codes: 
CAS Registry Number 968-93-4 (see NLM ChemIDplus info)
FDA UNII Code 6J9BLA949Q
ChEBI ID CHEBI:9460 (see ChEBI info)
NSC Code 23759 (see NCI DTP info)
PDQ Closed Trial Search ID 42916
PDQ Open Trial Search ID 42916 (check for NCI PDQ open clinical trial info)
UMLS CUI C0039600

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C19H24O3
code C2301
Contributing_Source FDA
Legacy_Concept_Name Testolactone
Semantic_Type Hormone
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2301

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