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Version: 16.11d (Release date: 2016-11-28)
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Alprazolam (Code C227)

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Terms & Properties

Preferred Name: Alprazolam

Definition: A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability.

NCI-GLOSS Definition: A drug used to treat anxiety disorders and panic attacks. It is being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine.

Label: Alprazolam

NCI Thesaurus Code: C227 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0699034  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ALPRAZOLAM
Alprazolam
alprazolam
Apo-Alpzar
Nu-Alpraz
Xanax

External Source Codes: 
CAS Registry Number 28981-97-7 (see NLM ChemIDplus info)
FDA UNII Code YU55MQ3IZY
ChEBI ID CHEBI:2611 (see ChEBI info)
PDQ Closed Trial Search ID 39659
PDQ Open Trial Search ID 39659 (check for NCI PDQ open clinical trial info)
UMLS CUI C0699034

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C17H13ClN4
code C227
Contributing_Source FDA
Legacy_Concept_Name Alprazolam
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C227

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