skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Prasterone (Code C2265)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Prasterone

Definition: A synthetic form of dehydroepiandrosterone with potential chemopreventive activity. Produced endogenously, dehydroepiandrosterone (DHEA) is an intermediate in the conversion of cholesterol to androgens and estrogens. Although the mechanisms of action of exogenously administered DHEA have not been fully illuminated, they may result in both direct and indirect physiologic effects. Direct effects include GABA-a receptor complex and NMDA receptor modulation, and enhanced pancreatic beta cell insulin secretion and antiglucocorticoid activities. (NCI04)

NCI-GLOSS Definition: A substance being studied in the prevention of cancer. It is a type of steroid.

Display Name: Prasterone

Label: Prasterone

NCI Thesaurus Code: C2265 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0011185  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
17-Hormoforin
3beta-Hydroxyandrost-5-en-17-one
5,6-Dehydroisoandrosterone
dehydroepiandrosterone
Dehydroepiandrosterone
Dehydroisoandrosterone
DHEA
Diandron
Fidelin
GL701
Prasterone
PRASTERONE
Therapeutic Dehydroepiandrosterone

External Source Codes: 
CAS Registry Number 53-43-0 (see NLM ChemIDplus info)
FDA UNII Code 459AG36T1B
ChEBI ID CHEBI:28689 (see ChEBI info)
NSC Code 9896 (see NCI DTP info)
PDQ Closed Trial Search ID 42419
PDQ Open Trial Search ID 42419 (check for NCI PDQ open clinical trial info)
UMLS CUI C0011185

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Adrenal insufficiency, replacement; Systemic lupus erythematosus, treatment and steroid treatment reduction
Chemical_Formula C19H28O2
code C2265
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Therapeutic_Dehydroepiandrosterone
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2265

Mainbox Bottom