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Version: 16.11d (Release date: 2016-11-28)
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Eflornithine (Code C226)

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Terms & Properties

Preferred Name: Eflornithine

Definition: A difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. This agent has been shown to induce apoptosis in leiomyoma cells. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the prevention of cancer. It belongs to the family of drugs called antiprotozoals.

Display Name: Eflornithine

Label: Eflornithine

NCI Thesaurus Code: C226 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0086156  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-(Difluoromethyl)-DL-ornithine
2-Difluoromethylornithine
Alpha-Difluoromethylornithine
D,L-alpha-Difluoromethylornithine
DFMO
Difluoromethylornithine
difluoromethylornithine
Difluromethylornithine
Eflornithine
EFLORNITHINE
eflornithine

External Source Codes: 
CAS Registry Number 67037-37-0 (see NLM ChemIDplus info)
CAS Registry Number 70052-12-9 (see NLM ChemIDplus info)
FDA UNII Code ZQN1G5V6SR
ChEBI ID CHEBI:41948 (see ChEBI info)
PDQ Closed Trial Search ID 39754
PDQ Open Trial Search ID 39754 (check for NCI PDQ open clinical trial info)
UMLS CUI C0086156

Other Properties:
Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Hirsutism, facial; Trypanosoma brucei gambiense (sleeping sickness) infection
Chemical_Formula C6H12F2N2O2
code C226
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Eflornithine
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C226

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