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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Platelet Factor 4 (Code C2251)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Recombinant Platelet Factor 4

Definition: A recombinant form of the endogenous chemokine platelet factor 4 with potential antiangiogenesis and antineoplastic activities. As a heparin-binding tetramer, recombinant platelet factor 4 inhibits growth factor-stimulated endothelial cell proliferation, migration, and angiogenesis; it has been shown that this agent inhibits fibroblast growth factor 2 (FGF2) angiogenic activity downstream from the FGF2 receptor. Its activity is antagonized by heparin. Recombinant platelet factor 4 may also directly inhibit the proliferation of some tumor cell types.

Label: Recombinant Platelet Factor 4

NCI Thesaurus Code: C2251 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3887655  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CXCL4
Platelet Factor 4
Recombinant Platelet Factor 4
rhPF4
rPF4

External Source Codes: 
CAS Registry Number 37270-94-3 (see NLM ChemIDplus info)
NSC Code 671662 (see NCI DTP info)
PDQ Closed Trial Search ID 42317
PDQ Open Trial Search ID 42317 (check for NCI PDQ open clinical trial info)
UMLS CUI C3887655

Other Properties:
     Name Value (qualifiers indented underneath)
code C2251
Legacy_Concept_Name Therapeutic_Platelet_Factor_4
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2251

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