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Version: 17.12d (Release date: 2017-12-26)
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Recombinant Interferon Alfa (Code C225)

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Terms & Properties

Preferred Name: Recombinant Interferon Alfa

Definition: A class of naturally-isolated or recombinant therapeutic peptides used as antiviral and anti-tumor agents. Alpha interferons are cytokines produced by nucleated cells (predominantly natural killer (NK) leukocytes) upon exposure to live or inactivated virus, double-stranded RNA or bacterial products. These agents bind to specific cell-surface receptors, resulting in the transcription and translation of genes containing an interferon-specific response element. The proteins so produced mediate many complex effects, including antiviral effects (viral protein synthesis); antiproliferative effects (cellular growth inhibition and alteration of cellular differentiation); anticancer effects (interference with oncogene expression); and immune-modulating effects (natural killer cell activation, alteration of cell surface antigen expression, and augmentation of lymphocyte and macrophage cytotoxicity). (NCI04)

Display Name: Recombinant Interferon Alfa

Label: Recombinant Interferon Alfa

NCI Thesaurus Code: C225 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1622507  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Alpha Interferon
Interferon Alfa
Leukocyte Interferon
Lymphoblast Interferon
Lymphoblastoid Interferon
Recombinant Interferon Alfa

External Source Codes: 
PDQ Closed Trial Search ID 40467
PDQ Open Trial Search ID 40467 (check for NCI PDQ open clinical trial info)
UMLS CUI C1622507

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For See specific agents.
code C225
Contributing_Source CTRP
Legacy_Concept_Name Therapeutic_Interferon_Alfa
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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