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Version: 17.06d (Release date: 2017-06-26)
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Tariquidar (Code C2246)

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Terms & Properties

Preferred Name: Tariquidar

Definition: An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It may help tumor cells respond again to drugs they have become resistant (unable to respond) to. Tariquidar is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.

Display Name: Tariquidar

Label: Tariquidar

NCI Thesaurus Code: C2246 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879444  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Tariquidar
tariquidar
TARIQUIDAR
XR9576

External Source Codes: 
CAS Registry Number 206873-63-4 (see NLM ChemIDplus info)
FDA UNII Code J58862DTVD
PDQ Closed Trial Search ID 37877
PDQ Open Trial Search ID 37877 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879444

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C38H38N4O6
code C2246
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tariquidar
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2246

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