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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Tariquidar (Code C2246)

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Terms & Properties

Preferred Name: Tariquidar

Definition: An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. (NCI04)

NCI-GLOSS Definition: A substance that is being studied in the treatment of cancer. It may help tumor cells respond again to drugs they have become resistant (unable to respond) to. Tariquidar is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.

Display Name: Tariquidar

Label: Tariquidar

NCI Thesaurus Code: C2246 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879444  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
CAS Registry Number 206873-63-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 37877
PDQ Open Trial Search ID 37877 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879444

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C38H38N4O6
code C2246
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Tariquidar
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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