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Version: 16.11d (Release date: 2016-11-28)
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Allopurinol (Code C224)

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Terms & Properties

Preferred Name: Allopurinol

Definition: A structural isomer of hypoxanthine. Allopurinol inhibits xanthine oxidase, an enzyme that converts oxypurines to uric acid. By blocking the production of uric acid, this agent decreases serum and urine concentrations of uric acid, thereby providing protection against uric acid-mediated end organ damage in conditions associated with excessive production of uric acid, i.e. the massive cell lysis associated with the treatment of some malignancies. (NCI04)

NCI-GLOSS Definition: A drug that lowers high levels of uric acid (a byproduct of metabolism) in the blood caused by some cancer treatments.

Display Name: Allopurinol

Label: Allopurinol

NCI Thesaurus Code: C224 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0002144  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,5-Dihydro-4H-pyrazolo[3,4-d]pryimidin-4-one
1,5-Dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one
1H-Pyrazolo[3,4-d]pyrimidin-4-ol
4'-HPP
4-Hydroxypyrazolo[3,4-d]pyrimidine
Allopurinol
ALLOPURINOL
allopurinol
Lopurin
Sigapurol
Zurinol

External Source Codes: 
CAS Registry Number 315-30-0 (see NLM ChemIDplus info)
FDA UNII Code 63CZ7GJN5I
ChEBI ID CHEBI:40279 (see ChEBI info)
NSC Code 101655 (see NCI DTP info)
NSC Code 1390 (see NCI DTP info)
PDQ Closed Trial Search ID 38452
PDQ Open Trial Search ID 38452 (check for NCI PDQ open clinical trial info)
UMLS CUI C0002144

Other Properties:
Name Value (qualifiers indented underneath)
Chemical_Formula C5H4N4O
code C224
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Allopurinol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C224

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