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Version: 17.06d (Release date: 2017-06-26)
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Phenethyl Isothiocyanate (Code C2233)

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Terms & Properties

Preferred Name: Phenethyl Isothiocyanate

Definition: An isothiocyanate found in cruciferous vegetables with chemopreventive and potential antitumor activities. Although the mechanism of action is unclear, phenethyl Isothiocyanate (PEITC) was shown to induce apoptosis in tumor cells, possibly mediated through its metabolic intermediates, reactive oxygen species (ROS). PEITC also is able to activate ERK and JNK signal transduction, which in turn induces expression of stress-responsive genes. Specifically, this agent has been shown to reactivate gene expression of a detoxification enzyme, glutathione S-transferase that is silenced in prostate carcinoma.

NCI-GLOSS Definition: A substance being studied in the prevention of cancer. It is a naturally occurring compound found in some cruciferous vegetables.

Display Name: Phenethyl Isothiocyanate

Label: Phenethyl Isothiocyanate

NCI Thesaurus Code: C2233 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0070558  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
2-Phenylethyl Isothiocyanate
Phenethyl Isothiocyanate
phenethyl isothiocyanate
Phenethyl isothiocyanate

External Source Codes: 
CAS Registry Number 2257-09-2 (see NLM ChemIDplus info)
ChEBI ID CHEBI:351346 (see ChEBI info)
NSC Code 87868 (see NCI DTP info)
PDQ Closed Trial Search ID 37977
PDQ Open Trial Search ID 37977 (check for NCI PDQ open clinical trial info)
PubMedID Primary Reference 16921492 (see PubMed Primary Reference info)
UMLS CUI C0070558

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H9NS
code C2233
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Phenethyl_Isothiocyanate
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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