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Version: 16.11d (Release date: 2016-11-28)
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Visilizumab (Code C2229)

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Terms & Properties

Preferred Name: Visilizumab

Definition: A humanized, non-Fc receptor (FcR)-binding IgG2 monoclonal antibody (MoAb) directed against CD3 with potential immunosuppressive activity. Visilizumab binds to invariant CD3 epsilon, one of the non-covalently-associated subunits of T-cell receptors (TCRs) on activated T-cells. Upon binding to the TCR/CD3 complex, visilizumab induces apoptosis, which may result in the selective clonal deletion of activated pathogenic T-cells. This MoAb is engineered with a substitution at amino acid residues 234 and 237 (Val3Ala) within the IgG2 Fc arm, rendering it unable to bind to type II FcRs; accordingly, this agent is less likely to activate type II FcR-expressing resting T-cells.

NCI-GLOSS Definition: A monoclonal antibody that binds to CD3 (a substance found on T-cells) and that is being studied as a treatment for graft-versus-host disease (GVHD). It belongs to the family of drugs called monoclonal antibodies.

Display Name: Visilizumab

Label: Visilizumab

NCI Thesaurus Code: C2229 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879551  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
HuM291
Nuvion
Visilizumab
VISILIZUMAB
visilizumab

External Source Codes: 
CAS Registry Number 219716-33-3 (see NLM ChemIDplus info)
FDA UNII Code H18SKU3289
NSC Code 711007 (see NCI DTP info)
PDQ Closed Trial Search ID 38685
PDQ Open Trial Search ID 38685 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879551

Other Properties:
Name Value (qualifiers indented underneath)
code C2229
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Monoclonal_Antibody_HuM291
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2229

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