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Version: 17.06d (Release date: 2017-06-26)
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Apolizumab (Code C2228)

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Terms & Properties

Preferred Name: Apolizumab

Definition: A humanized monoclonal antibody directed against 1D10, a polymorphic determinant on the HLA-DR beta chain that is expressed on normal and neoplastic B cells. Apolizumab induces complement-mediated cytotoxicity, antibody-dependent cell-mediated cytotoxicity, and apoptosis of 1D10 antigen-positive B cells in vitro. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of hematologic (blood) cancers. Apolizumab binds to a protein called ID10, which is found on the surface of some types of immune cells and cancer cells. It may help the immune system kill cancer cells. It is a type of monoclonal antibody.

Display Name: Apolizumab

Label: Apolizumab

NCI Thesaurus Code: C2228 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C1122758  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1D10 Anti-lymphoma Antibody
Apolizumab
APOLIZUMAB
apolizumab
MoAb: Hu1D10
MoAb Hu1D10
Monoclonal antibody 1D10
Monoclonal Antibody Hu1D10
Remitogen

External Source Codes: 
CAS Registry Number 267227-08-7 (see NLM ChemIDplus info)
FDA UNII Code G88KCP51RE
NSC Code 710066 (see NCI DTP info)
NSC Code 704867 (see NCI DTP info)
PDQ Closed Trial Search ID 38451
PDQ Open Trial Search ID 38451 (check for NCI PDQ open clinical trial info)
UMLS CUI C1122758

Other Properties:
     Name Value (qualifiers indented underneath)
code C2228
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Apolizumab
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: Yes  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2228

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