skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Zosuquidar Trihydrochloride (Code C2225)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Zosuquidar Trihydrochloride

Definition: A difluorocyclopropyl quinoline. Zosuquidar trihydrochloride binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents. (NCI04)

NCI-GLOSS Definition: A substance being studied in the treatment of cancer. Zosuquidar trihydrochloride may help kill cancer cells that are resistant to anticancer drugs.

Label: Zosuquidar Trihydrochloride

NCI Thesaurus Code: C2225 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0528372  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(R)-4-((1aR,6R,10bS)-1,2-Difluoro-1,1a,6,10b-tetrahydrodibenzo(a,e)cyclopropa(c)cycloheptan-6-yl)-alpha-((5-quinoloyloxy)methyl)-1-piperazineethanol, Trihydrochloride
LY335979
ZOSUQUIDAR TRIHYDROCHLORIDE
Zosuquidar Trihydrochloride
zosuquidar trihydrochloride

External Source Codes: 
CAS Registry Number 167465-36-3 (see NLM ChemIDplus info)
FDA UNII Code 813AGY3126
NSC Code 725086 (see NCI DTP info)
PDQ Closed Trial Search ID 43659
PDQ Open Trial Search ID 43659 (check for NCI PDQ open clinical trial info)
UMLS CUI C0528372

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C32H31F2N3O2.3ClH
code C2225
Contributing_Source FDA
Legacy_Concept_Name Zosuquidar_Trihydrochloride
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2225

Mainbox Bottom