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Version: 17.06d (Release date: 2017-06-26)
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Iodine I 131 Monoclonal Antibody TNT-1/B (Code C2223)

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Terms & Properties

Preferred Name: Iodine I 131 Monoclonal Antibody TNT-1/B

Definition: An iodine 131 labeled radioimmunoconjugate of monoclonal antibody (MOAB) TNT-1/B with radioimaging and antineoplastic properties. MOAB TNT-1/B was developed for radioimmunotherapy of solid tumors, designated as Tumor Necrosis Treatment (TNT). TNT exploits the presence of degenerating and necrotic cells within tumors by utilizing MOAbs directed against universal, intracellular nucleosomal determinants consisting of histone H1 and DNA. This MOAB was conjugated with biotin (B) molecules, which increase pharmacokinetic performance of the monoclonal antibody. MOAB TNT-1/B delivers I 131 to tumor cells and results in the targeted imaging and/or destruction of cells with exposed necrotic antigens.

Display Name: Iodine I 131 Monoclonal Antibody TNT-1/B

Label: Iodine I 131 Monoclonal Antibody TNT-1/B

NCI Thesaurus Code: C2223 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879273  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
iodine I 131 MOAB TNT-1/B
Iodine I 131 Monoclonal Antibody TNT-1/B
I 131 MOAB TNT-1/B
I 131 Monoclonal Antibody TNT-1/B

External Source Codes: 
PDQ Closed Trial Search ID 43561
PDQ Open Trial Search ID 43561 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879273

Other Properties:
     Name Value (qualifiers indented underneath)
code C2223
Contributing_Source CTRP
Legacy_Concept_Name I_131_Monoclonal_Antibody_TNT-1_B
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2223

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