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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Interleukin-12 Gene (Code C2222)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Interleukin-12 Gene

Definition: The DNA sequence that encodes the protein cytokine interleukin-12 (IL-12). When introduced as the complementary DNA (cDNA) form into tumor cells by, for example, a genetically engineered adenovirus vector, the transfected IL-12 cDNA expresses IL-12 which activates antitumoral natural killer (NK) cells and CD8+ T-cells and stimulates the secretion of interferon-gamma (IFN-gamma), potentially inhibiting tumor cell metastasis. This gene therapy may also result in IL-12-mediated inhibition of vascular endothelial growth factor (VEGF) and enhancement of matrix metalloproteinases (MMPs). (NCI04)

Display Name: Interleukin-12 Gene

Label: Interleukin-12 Gene

NCI Thesaurus Code: C2222 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0879338  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
IL-12 gene
Interleukin-12 Gene
pIL-12
Plasmid DNA Encoding Human Interleukin-12
Plasmid IL-12

External Source Codes: 
PDQ Closed Trial Search ID 43632
PDQ Open Trial Search ID 43632 (check for NCI PDQ open clinical trial info)
UMLS CUI C0879338

Other Properties:
     Name Value (qualifiers indented underneath)
code C2222
Contributing_Source CTRP
Legacy_Concept_Name Interleukin-12_Gene
Semantic_Type Gene or Genome
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2222

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