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Version: 17.12d (Release date: 2017-12-26)
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Imidazole Mustard (Code C2216)

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Terms & Properties

Preferred Name: Imidazole Mustard

Definition: A synthetic derivative of imidazole with potent antineoplastic properties. Imidazole mustard alkylates DNA, preferentially at guanine residues, resulting in DNA interstrand crosslinks and inhibition of DNA replication and RNA and protein synthesis. (NCI04)

Label: Imidazole Mustard

NCI Thesaurus Code: C2216 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0063382  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
5-[3, 3-Bis(2-chloroethyl)-1-triazeno]-imidazole-4-carboxamide
5-[3, 3-Bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide
Imidazole Mustard
Imidazole mustard
TIC Mustard
TIC mustard

External Source Codes: 
CAS Registry Number 5034-77-5 (see NLM ChemIDplus info)
NSC Code 82196 (see NCI DTP info)
PDQ Closed Trial Search ID 39483
PDQ Open Trial Search ID 39483 (check for NCI PDQ open clinical trial info)
UMLS CUI C0063382

Other Properties:
     Name Value (qualifiers indented underneath)
code C2216
Legacy_Concept_Name Imidazole_Mustard
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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