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Version: 17.06d (Release date: 2017-06-26)
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Liposomal Daunorubicin Citrate (Code C2213)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Liposomal Daunorubicin Citrate

Definition: A liposome-encapsulated form of the citrate salt of the anthracycline antineoplastic antibiotic daunorubicin. Daunorubicin intercalates into DNA and interacts with topoisomerase II, thereby inhibiting DNA replication and repair and RNA and protein synthesis. Liposomal delivery of doxorubicin citrate improves drug penetration into tumors and decreases drug clearance, thereby increasing the duration of therapeutic drug effects.

Display Name: Liposomal Daunorubicin Citrate

Label: Liposomal Daunorubicin Citrate

NCI Thesaurus Code: C2213 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0717668  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Daunorubicin Citrate Liposome Injection
Daunorubicin Liposomal
DaunoXome
Liposomal Daunorubicin
Liposomal Daunorubicin Citrate

External Source Codes: 
NSC Code 697732 (see NCI DTP info)
PDQ Closed Trial Search ID 37796
PDQ Open Trial Search ID 37796 (check for NCI PDQ open clinical trial info)
UMLS CUI C0717668

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Acute Nonlymphocytic Leukemia; Acute Lymphocytic Leukemia; Advanced HIV-associated Karposi Sarcoma.
code C2213
Contributing_Source CTRP
Legacy_Concept_Name Liposomal_Daunorubicin_Citrate
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C2213

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